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  1. Table 8: Patients Receiving Effexor XR in Premarketing Clinical Studies Indication Effexor XR MDD 705a GAD 1,381 SAD 819 PD 1,314 a In addition, in the effexor xr premarketing assessment of Effexor, multiple doses were administered to 2,897 patients in studies for MDD. Effects Of Other Drugs On Effexor XR Figure 1: Effect of interacting drugs on the pharmacokinetics of venlafaxine and active metabolite O-desmethylvenlafaxine (ODV). Examination of gender subsets of the population studied did not reveal any differential responsiveness on the basis of gender.